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英文名称 LRP/MVP 中文名称 肺耐药相关蛋白抗体 别 名 A2MR; Lung resistance related protein; Alpha 2 macroglobulin receptor; alpha 2MR; APOER; A... 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 hu,rat,mo 产品类型 研究领域 肿瘤 细胞生物 免疫学 细胞凋亡 免疫荧光 激光共聚焦 流氏细胞检测 蛋白分子量 Predicted Molecular Weight: 95kDa 性 状 Lyophilized or Liquid 浓 度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human LRP C-terminus. 亚 型 IgG 产品应用 WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100（石蜡切片需做抗原修复）
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
相关产品 Western Blotting常用试剂 免疫组化常用试剂 各种标记二抗 免疫组化套装检测试剂盒 参考文献 PubMed 产品介绍 LRP (originally named Lung Resistance-related Protein) Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein(originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-beta, and may mediate drug resistance, perhaps via a transport process.LRP或称MVP(Major vault protein)为肺耐药相关蛋白。其耐药机制与该蛋白质参与细胞核-浆的运输有关。他在正常细胞有广泛分布，对多种药物耐药的癌细胞呈过度表达，亦属多药耐药(MDR)中的一种表型，可表达于许多肿瘤组织中，阳性者预示对化疗不敏感，主要用于各种恶性肿瘤的研究。
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
相关产品 Western Blotting常用试剂 免疫组化常用试剂 各种标记二抗 免疫组化套装检测试剂盒 参考文献 PubMed 产品介绍 LRP (originally named Lung Resistance-related Protein) Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein(originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the104-kD rat major vault protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-beta, and may mediate drug resistance, perhaps via a transport process.LRP或称MVP(Major vault protein)为肺耐药相关蛋白。其耐药机制与该蛋白质参与细胞核-浆的运输有关。他在正常细胞有广泛分布，对多种药物耐药的癌细胞呈过度表达，亦属多药耐药(MDR)中的一种表型，可表达于许多肿瘤组织中，阳性者预示对化疗不敏感，主要用于各种恶性肿瘤的研究。
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