牛蒡子苷元试剂

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牛蒡子苷元  (-)-Arctigenin

Antitumor agent
 
Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca2+. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
 
PRODUCT PROPERTIES

Alternative Name:
  
 (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
Source/Host:
  
 Isolated from Arctium lappa.
Solubility:
  
 Soluble in DMSO (34mg/ml, heating, sonication); sparingly soluble in water.
Long Term Storage:
  
 -20°C
MW:
  
 372.4
CAS:
  
 7770-78-7
Formula:
  
 C21H24O6
Purity:
  
 ≥97% (HPLC)
Appearance:
  
 White to off-white solid.
 
 
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