厂商 ：西安金绿生物工程技术有限公司
陕西 西安- 主营产品：
- 苦参碱
- 柚皮甙
- 左旋肉碱
联系电话 ：15129390969
商品详细描述
产品简介
THE BRIEF INTRODUCTION TO Apigenin
[产品名称-KinGreen]: 芹菜素
[英文名称-KinGreen]: Apigenin
[产品别名-KinGreen]: 5,7,4-三羟基黄酮;芹菜素;芹黄素;甘菊,黄春菊;芹菜(甙)配基;芹菜甙元;芹菜苷元;芹菜甙元[西安金绿]。
[产品来源-KinGreen]: 伞形科植物旱芹 Apium graveolens var.dulce 叶，此外广泛存在于多种水果、蔬菜、豆类和茶叶,玄参科植物水蔓青,百合科毛叶藜芦,松科植物中[西安金绿]。
[产品CAS-KinGreen]: 520-36-5
[ENNISC-KinGreen]: 208-292-3
[分 子 式-KinGreen]: C15H10O5
[分 子 量-KinGreen]: 270.24
[物理性状-KinGreen]: 黄色针晶，属于黄酮类[西安金绿]。几乎不溶于水，部分溶于热酒精，溶于稀KOH溶液。
[产品熔点-KinGreen]: 345-350℃
[产品规格-KinGreen]: 西安金绿生物供应芹菜素98%
[检测方法-KinGreen]: 高效液相色谱法
[ Product—Brand ]: 西安金绿-Xi’an KinGreen
[药理作用-KinGreen]: 芹菜素具有抑制致癌物质的致癌活性；作为治疗HIV和其它病毒感染的抗病毒药物；MAP激酶的抑制剂；治疗各种炎症；抗氧化剂；镇静、安神；降压。与其他黄酮类物质(槲皮素、山奈黄酮)相比具有低毒、无诱变性等特点[西安金绿]。
[Latest-Study-KinGreen]: Apigenin is a natural dietary flavonoid. It has recently been shown to have anticancer effects on prostate and ovarian cancer cells. However, the molecular basis of the effect of apigenin on cancer cells remains to be elucidated. In this study, we found that apigenin inhibited A549 lung cancer cell proliferation and vascular endothelial growth factor (VEGF) transcriptional activation in a dose-dependent manner. In an attempt to understand the mechanism of apigenin-inhibited VEGF expression, we found that apigenin inhibited VEGF transcriptional activation through the hypoxia-inducible factor 1 (HIF-1) binding site and specifically decreased HIF-1 but not HIF-1 subunit expression in the cells. In our efforts to understand the signaling pathway that mediates VEGF transcriptional activation, we found that apigenin inhibited AKT and p70S6K1 activation. When testing the effect of apigenin in vivo, we found that apigenin significantly inhibited tumor growth in nude mice. Apigenin inhibited HIF-1 and VEGF expression in the tumor tissues, suggesting an inhibitory effect of apigenin on angiogenesis. To confirm this, we showed that apigenin inhibited angiogenesis in nude mice using the Matrigel assay. HIF-1 and VEGF are well known inducers of angiogenesis. Our data suggested that apigenin may inhibit human lung cancer angiogenesis by inhibiting HIF-1 and VEGF expression, thus providing a novel explanation for the anticancer action of apigenin. The information above is provided by Xi’an KinGreen Bioengineering CO.,LTD.
[供应厂家-KinGreen]: 西安金绿生物工程技术有限公司
[产品应用-KinGreen]: 治疗HIV和其它病毒感染的抗病毒药物以及各种炎症。
[保存方法-KinGreen]: 通风干燥，阴凉，避强光。
[产品包装-KinGreen]:1KG /灭菌铝箔袋；25KG /纸板桶；西安金绿生物工程技术有限公司可根据客户要求对产品具体包装。
[有效期限-KinGreen]: 24个月
THE BRIEF INTRODUCTION TO Apigenin
[产品名称-KinGreen]: 芹菜素
[英文名称-KinGreen]: Apigenin
[产品别名-KinGreen]: 5,7,4-三羟基黄酮;芹菜素;芹黄素;甘菊,黄春菊;芹菜(甙)配基;芹菜甙元;芹菜苷元;芹菜甙元[西安金绿]。
[产品来源-KinGreen]: 伞形科植物旱芹 Apium graveolens var.dulce 叶，此外广泛存在于多种水果、蔬菜、豆类和茶叶,玄参科植物水蔓青,百合科毛叶藜芦,松科植物中[西安金绿]。
[产品CAS-KinGreen]: 520-36-5
[ENNISC-KinGreen]: 208-292-3
[分 子 式-KinGreen]: C15H10O5
[分 子 量-KinGreen]: 270.24
[物理性状-KinGreen]: 黄色针晶，属于黄酮类[西安金绿]。几乎不溶于水，部分溶于热酒精，溶于稀KOH溶液。
[产品熔点-KinGreen]: 345
[产品规格-KinGreen]: 西安金绿生物供应芹菜素98%
[检测方法-KinGreen]: 高效液相色谱法
[ Product—Brand ]: 西安金绿-Xi’an KinGreen
[药理作用-KinGreen]: 芹菜素具有抑制致癌物质的致癌活性；作为治疗HIV和其它病毒感染的抗病毒药物；MAP激酶的抑制剂；治疗各种炎症；抗氧化剂；镇静、安神；降压。与其他黄酮类物质(槲皮素、山奈黄酮)相比具有低毒、无诱变性等特点[西安金绿]。
[Latest-Study-KinGreen]: Apigenin is a natural dietary flavonoid. It has recently been shown to have anticancer effects on prostate and ovarian cancer cells. However, the molecular basis of the effect of apigenin on cancer cells remains to be elucidated. In this study, we found that apigenin inhibited A549 lung cancer cell proliferation and vascular endothelial growth factor (VEGF) transcriptional activation in a dose-dependent manner. In an attempt to understand the mechanism of apigenin-inhibited VEGF expression, we found that apigenin inhibited VEGF transcriptional activation through the hypoxia-inducible factor 1 (HIF-1) binding site and specifically decreased HIF-1 but not HIF-1 subunit expression in the cells. In our efforts to understand the signaling pathway that mediates VEGF transcriptional activation, we found that apigenin inhibited AKT and p70S6K1 activation. When testing the effect of apigenin in vivo, we found that apigenin significantly inhibited tumor growth in nude mice. Apigenin inhibited HIF-1 and VEGF expression in the tumor tissues, suggesting an inhibitory effect of apigenin on angiogenesis. To confirm this, we showed that apigenin inhibited angiogenesis in nude mice using the Matrigel assay. HIF-1 and VEGF are well known inducers of angiogenesis. Our data suggested that apigenin may inhibit human lung cancer angiogenesis by inhibiting HIF-1 and VEGF expression, thus providing a novel explanation for the anticancer action of apigenin. The information above is provided by Xi’an KinGreen Bioengineering CO.,LTD.
[供应厂家-KinGreen]: 西安金绿生物工程技术有限公司
[产品应用-KinGreen]: 治疗HIV和其它病毒感染的抗病毒药物以及各种炎症。
[保存方法-KinGreen]: 通风干燥，阴凉，避强光。
[产品包装-KinGreen]:
[有效期限-KinGreen]: 24个月
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