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商品详细描述
褪黑素/Melatonin
SigmaM5250 powder, ≥98% (TLC)
CAS号: 73-31-4
经验分子式(希尔表示法): C13H16N2O2
分子量: 232.28
Biochem/physiol Actions
Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action参考文献
Reiter, R.J., et al., Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntingtons disease, Alzheimers disease and parkinsonism. Ann. N.Y. Acad. Sci. 890, 471-485, (1999) 摘要Goldman, B.D., The circadian timing system and reproduction in mammals. Steroids 64, 679, (1999) 摘要
Cuzzocrea, S, et al., The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J. 13, 1930, (1999) 摘要
Sainz, R.M., et al., Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell. Mol. Life Sci. 60, 1407-1426, (2003) 摘要
Sanchez-Barcelo, E.J., et al., Melatonin and mammary cancer: a short review. Endocrinol. Relat. Cancer 10, 153-159, (2003)
Assayed, M.E., and Abd El-Aty, A.M., Protection Of Rat Chromosomes By Melatonin Against Gamma Radiation-induced Damage. Mol. Cell. 677, 14-20, (2009)
Welp, A., et al., Development And Validation Of A High Throughput Direct Radioimmunoassay For The Quantitative Determination Of Serum And Plasma Melatonin (N-acetyl-5-methoxytryptamine) In Mice. J. Immunol. Methods 358, 1-8, (2010) 摘要
Merck 14,5816
Beil. 22,V,12,42
FT-IR 2 (3), 3606:D / FT-IR 1 (2), 677:A / FT-NMR 1 (3), 156:C / IR-Spectra (3), 1260:A / IR-Spectra (2), 1095:G / NMR-Reference 2 (2), 546:C / RegBook 1 (2), 2421:A / Sigma FT-IR 1 (1), 678:D / Structure Index 1, 384:D:3
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